Twelve-month retention on antiretroviral therapy
It measures progress in increasing survival among infected adults and children by maintaining them on antiretroviral therapy.
One of the goals of any antiretroviral therapy. programme is to increase survival among infected individuals. As antiretroviral therapy. is scaled up in countries around the world, it is also important to understand why and how many people drop out of treatment programmes. These data can be used to demonstrate the effectiveness of those programmes and highlight obstacles to expanding and improving them.
Number of adults and children who are still alive and on antiretroviral therapy at 12 months after initiating treatment.
Total number of adults and children who initiated antiretroviral therapy who were expected to achieve 12-month outcomes within the reporting period,* including those who have died since starting antiretroviral therapy, those who have stopped antiretroviral therapy, and those recorded as lost to follow-up at month 12.
Numerator / Denominator
Programme monitoring tools; cohort/group analysis forms
Antiretroviral therapy registers and antiretroviral therapy cohort analysis report
The reporting period is defined as any continuous 12-month period that has
ended within a pre-defined number of months from the submission of the report.
The pre-defined number of months can be determined by national reporting
requirements. If the reporting period is January 1 to December 31, 2012, countries
will calculate this indicator by using all patients who started antiretroviral therapy.
any time during the 12-month period from January 1 to December 31, 2011. If the
reporting period is July 1, 2011 to June 30, 2012, countries will include patients
who started antiretroviral therapy from July 1, 2010 to June 30, 2011
A 12-month outcome is defined as the outcome (i.e., whether the patient is still
alive and on antiretroviral therapy, dead or lost to follow-up) at 12 months after
starting antiretroviral therapy. For example, patients who started antiretroviral
therapy during the 12-month period from January 1 to December 31, 2010 will
have reached their 12-month outcomes for the reporting period of January 1 to
December 31, 2012
• Age ( • Pregnancy status at start of therapy
• Breastfeeding status at start of therapy
Age group: (greater than) 15 years
Gender: Female, Male
Pregnancy status: Not Pregnant, Pregnant
The numerator requires that adult and child patients must be alive and on antiretroviral therapy at 12 months after their initiation of treatment. For a comprehensive understanding of survival, the following data must be collected:
• Number of adults and children in the antiretroviral therapy start-up groups initiating antiretroviral therapy at least 12 months prior to the end of the reporting period;
• Number of adults and children still alive and on antiretroviral therapy at 12 months after initiating treatment.
The numerator does not require patients to have been on antiretroviral therapy continuously for the 12-month period. Patients who may have missed one or two appointments or drug pick-ups, and temporarily stopped treatment during the 12 months since initiating treatment but are recorded as still being on treatment at month 12 are included in the numerator. On the contrary, those patients who have died, stopped treatment or been lost to follow-up at 12 months since starting treatment are not included in the numerator.
For example, for those patients who started antiretroviral therapy in May 2012, if at any point during the period May 2012 to May 2013 these patients die, are lost to follow-up (and do not return) or stop treatment (and do not restart), then at month 12 (May 2013), they are not on antiretroviral therapy, and not included in the numerator. Conversely, a patient who started antiretroviral therapy in May 2012 and who missed an appointment in June 2012, but is recorded as on antiretroviral therapy in May 2013 (at month 12) is on antiretroviral therapy and will be included in the numerator. What is important is that the patient who has started antiretroviral therapy in May 2012 is recorded as being alive and on antiretroviral therapy after 12 months, regardless of what happens from May 2012 to May 2013.
ART registries should include a number of variables describing the patients. For example the age of the patient at the start of ART. In addition many registries will include a tick box indicating whether the patient was pregnant or was breastfeeding at the start of ART. ART retention for these sub-sets of women should be calculated to determine ART retention at 12 months for pregnant women and for breastfeeding women.
The denominator is the total number of adults and children in the antiretroviral therapy start-up groups who initiated antiretroviral therapy at any point during the 12 months prior to the beginning of the reporting period, regardless of their 12-month outcome.
For example, for the reporting period January 1 to December 31, 2012, this will include all patients who started antiretroviral therapy during the 12-month period from January 1 to December 31, 2011. This includes all patients, both those on antiretroviral therapy as well as those who are dead, have stopped treatment or are lost to follow-up at month 12.
At the facility level, the number of adults and children on antiretroviral therapy at 12 months includes patients who have transferred in at any point from initiation of treatment to the end of the 12-month period and excludes patients who have transferred out during this same period to reflect the net current cohort at each facility. In other words, at the facility level, patients who have transferred out will not be counted either in the numerator or the denominator. Similarly, patients who have transferred in will be counted in both the numerator and denominator. At the national level, the number of transferred-in patients should match the number of transferred-out patients. Therefore, the net current cohort (the patients whose outcomes the facility is currently responsible for recording—the number of patients in the start-up group plus any transfers in, minus any transfers out) at 12 months should equal the number in the start-up cohort group 12 months prior.
Using this denominator may underestimate true “survival”, since a proportion of those lost to follow-up are alive. The number of people alive and on antiretroviral therapy (i.e. retention on antiretroviral therapy) in a treatment cohort is captured here.
Priority reporting is for aggregate survival reporting. If comprehensive cohort patient registries are available then it is encouraged for countries to track retention on treatment at 24, 36, and 48 months and yearly thereafter. This will enable comparison over time of survival on ART. As it stands, it is possible to identify whether survival at 12 months increases or decreases over time. However, it is not possible to attribute cause to these changes. For example, if survival at 12 months increases over time, this may reflect an improvement in care and treatment practices or earlier initiation of ART. The retention on antiretroviral therapy at 12 months therefore needs to be interpreted in view of the baseline characteristics of the cohort of patients at the start of antiretroviral therapy: mortality will be higher in sites where patients accessed antiretroviral therapy at a later stage of infection. Therefore, collection and reporting of survival over longer durations of treatment outcomes may provide a better picture of the long-term effectiveness of ART.